Theolytics, a clinical-stage biotechnology company developing next-generation oncolytic immunotherapies, has dosed the first patient in its Phase I/IIa multi-centre, open-label first-in-human trial (OCTOPOD - NCT06618235) of THEO-260 in patients with advanced-stage platinum-resistant ovarian cancer (PROC).
The Phase I/IIa clinical trial is designed to investigate the safety and tolerability of THEO-260 administered via intravenous delivery and determine the recommended Phase 2 dose. Demonstration of THEO-260’s differentiated oncolytic mechanism in the clinic will be supported by comprehensive biomarker analysis.
Theolytics CSO and Co-Founder Margaret Duffy PhD, commented on the milestone:
Enrolling the first patient into our Phase I/IIa trial for THEO-260 marks a major milestone for Theolytics. As a team, we seek to deliver effective new treatment options for the many women who suffer from platinum resistant ovarian cancer. Using our discovery platform, THEO-260 has been developed to combat the stromal rich nature of this advanced solid cancer, and we look forward to reporting on the progress of this trial.