Hosted by Professor Caetano Reis e Sousa this 8th edition of Medicine at the Crick will focus on our current understanding of innate immune sensing of nucleic acids and review its role in immunity to infection, cancer, autoinflammation and autoimmunity.
Nucleic acids, long known as encoders of genetic information, can play an additional role in triggering innate immune sensors that alert the body to cellular stress or the presence of potential pathogens. Nucleic acid-sensing can be beneficial and drive immune reactions that limit infection or promote cancer immunity. However, it can misfire or become dysregulated, contributing to chronic inflammatory reactions and autoimmune disease.
Prof Andrea Ablasser (Swiss Federal Institute of Technology Lausanne - EPFL)
Prof Jan Rehwinkel (University of Oxford)
Dr Vanessa Sancho-Shimizu (Imperial College London)
Prof Yanick Crow (The University of Edinburgh & Institute Imagine, Paris)
Prof Ann Marshak-Rothstein (University of Massachusetts Medical School)