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PGN-EDODM1 was generally well-tolerated, with all adverse events being mild or moderate, and no serious adverse events reported. The mean splicing correction observed with PGN-EDODM1 (n=6) was 7.3%, compared to 6.8% for the placebo (n=2). Excluding one outlier patient, the treatment group showed a mean splicing correction of 22.9% (n=5). Promising trends were seen in vHOT in the PGN-EDODM1 treated group. The company is on track to report clinical data from the 10 mg/kg multiple dose cohort in the second half of 2026, with sufficient cash expected to fund operations into the second half of 2027.
Paul Leeson
PhD FRCP FESC Paul Leeson - Professor of Cardiovascular Medicine and Academic Lead for Innovation, Medical Sciences Division, University of Oxford
Professor Heidi Johansen-Berg
FRS FMedSci Professor Heidi Johansen-Berg - Pro-Vice Chancellor (Strategic Initiatives); Associate Head (Research and Innovation) of Medical Sciences Division; Professor of Cognitive Neuroscience, Nuffield Department of Clinical Neurosciences, University of Oxford
Professor Catherine Green
OBE Professor Catherine Green - Head of the Clinical Biomanufacturing Facility at Nuffield Department of Medicine and Associate Professor in Chromosome Dynamics at the Wellcome Centre for Human Genetics, University of Oxford
Professor Krina Zondervan
MSc DPhil FRCOG FMedSci Professor Krina Zondervan - Head of the Nuffield Dept of Women's & Reproductive Health; Professor of Reproductive and Genomic Epidemiology; Co-Director Endometriosis Care Centre, University of Oxford
Professor Dame Molly Stevens
FRS FREng FRPharm FRSB FRSC FIMMM FCGI FIsntP Professor Dame Molly Stevens - John Black Professor of Bionanoscience, University of Oxford; Research Director for Biomedical Materials, Imperial College London
Professor Bethan Psaila
MA MBBS MRCP FRCPath PhD Professor Bethan Psaila - Associate Professor of Haematology and Cancer Research, MRC Weatherall Institute of Molecular Medicine, University of Oxford; Co-founder of Alethiomics
Peter Callow
Peter Callow - Divisional Financial Controller, Medical Sciences Division, University of Oxford
Professor Angela Russell
Professor Angela Russell - Professor of Medicinal Chemistry, University of Oxford; Bernard Taylor Fellow and Tutor in Organic Chemistry
Dr Simon Warner
Dr Simon Warner - Head of Licensing and Ventures, Life Sciences, Oxford University Innovation
Professor Duncan Richards
Professor Duncan Richards - Professor of Medicine Head of Department of Medicine, University of Cambridge
Professor Matthew Wood
FMedSci Professor Matthew Wood - Professor of Neuroscience and Deputy Head of the Medical Sciences Division, University of Oxford
